Die Rolle der¹³¹J-Metajod-benzylguanidin-(MIBG-) Szintigraphie in der Diagnostik der intestinalen Karzinoide

lodine-131 metaiodobenzylguanidine (¹³¹I-MIBG) is concentrated in a variety of neuroendocrine tumors, such as pheochromocytoma and neuroblastoma. Other neuroendocrine tumors from the APUD-cell system such as carcinoid tumors, may posses this uptake capability as well. We investigated 11 patients suffering from intestinal carcinoid with ¹³¹I-MIBG in order to determine the value of MIBG scintigraphy in these tumors. MIBG scans were positive in 5 out of 11 patients (45%). False-positive MIBG-scans did not occur. No correlation between MIBG uptake, clinical symptoms and urinary 5-HIAA level could be found.

Zusammenfassung

¹³¹J-Metajodbenzylguanidin (¹³¹J-MIBG) wird in einer Reihe von neuroendokrinen Tumoren, wie z. B. den Phäochromozytomen und Neuroblastomen, angereichert. Auch andere neuroendokrine Tumoren aus dem APUD-Zellsystem, wie z.B. die Karzinoide, besitzen potentiell diese Speicherfähigkeit. Wir untersuchten 11 Patienten mit intestinalem Karzinoid mit ¹³¹J-MIBG, um den Wert der MIBG-Szintigraphie bei diesen Tumoren zu bestimmen. Fünf der 11 Patienten (45%) zeigten einen positiven MIBG-Befund; falsch-positive MIBG-Befunde traten nicht auf. Eine Korrelation zwischen MIBG-Speicherung und klinischer Symptomatik sowie laborchemischen Befunden fand sich nicht.

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